Carpe Diem

Yuan et al. 2024 published in Communications Medicine on Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations.

Yuan et al. 2024 published in Nature Communications on Exome-wide association study identifies KDELR3 mutations in extreme myopia. This is first time to identify gene causing extreme myopia

Yu et al. 2023 published in JAMA Network Open on Whole-Exome Sequencing Among School-Aged Children With High Myopia. This study revealed the genetic factor of high myopia, and is expected to guide future research and clinical diagnosis of HM.

Five Years of the Institute of Biomedical Big Data.

Congratulations to Xiangyi Yu on graduation.

Su et al. 2023 published in Cell reports on Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population.

Xue et al. 2022 published in eBioMedicine on Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.

Congratulations to Fukun Chen and Ji Zhang on graduation.

Welcome to Yue Zhang, a graduate student who has joined the IBBD and Yuan group.

Yuan et al. 2021 published in NPJ genomic medicine on Loss of grand histone H3 lysine 27 trimethylation domains mediated transcriptional activation in esophageal squamous cell carcinoma.

Ye et al. 2021 published in Nature Communications on Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis.

Yuan et al. 2021 published in NAR Genomics and Bioinformatics on EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases.

Xu et al. 2021 published in Ophthalmology on COVID-19 Quarantine Reveals Grade-specific Behavioral Modification of Myopia.

Yuan et al. 2020 published in IOVS on Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19.

Congratulations to Dandan Fan and Qi Jiang on graduation.

First day of the lab.