T he scPBS (single-cell Polygenic Burden Score) is a method to evaluate polygenic burden enrichment of rare variants in individual cells of scRNA-seq data to consider heterogeneity within each cell type.

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T he MAGICpipeline, a convenient and open-access analysis pipeline, to estimate the genetic associations of rare and common variants in large-scale case-control WES studies. Gene-based rare variants association analyses were assessed by incorporating multiple variant pathogenic annotations and statistical methods. The protocol also used Weighted Correlation Network Analysis (WGCNA), a systems biology method, to identify disease-related modules and hub genes.

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E yeDiseases is a omics database which integrates gene, mutation, RNA expression, Single-Cell RNAseq, methylation, chromatin accessibility and histone modification data. The database provides three functions, ‘Genetics’, ‘Expression’, and ‘Epigenomics’, to help researchers visualize the relationships between eye disease and candidate genes. Data in this database were performed extended functional annotation, such as gene-disease networks, Gene Ontology, Pathway analysis,Gene significance score and Co-expression.Our mission is to provide the scientific community with freely available information on eye disease-related gene, RNA expression and epigenetic regulation.

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